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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL203804
Molecular formula	C23H27Cl2N5O
IUPAC name	2-(2,4-dichloroanilino)-N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]acetamide
Molecular weight	460.403
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.2
Synonyms	2-(2,4-dichlorophenylamino)-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methylquinolin-6-yl)acetamide BDBM50177305 SCHEMBL5910743 2-(2,4-dichloro-phenylamino)-n-{2-[(2-dimethylamino-ethyl)-methyl-amino]-4-methyl-quinolin-6-yl}-acetamide ABHLVXSUCSLTLA-UHFFFAOYSA-N
Inchi Key	ABHLVXSUCSLTLA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H27Cl2N5O/c1-15-11-22(30(4)10-9-29(2)3)28-20-8-6-17(13-18(15)20)27-23(31)14-26-21-7-5-16(24)12-19(21)25/h5-8,11-13,26H,9-10,14H2,1-4H3,(H,27,31)
PubChem CID	44407951
ChEMBL	CHEMBL203804
IUPHAR	N/A
BindingDB	50177305
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	125.0 nM	PMID16289819	BindingDB,ChEMBL

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