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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Type-1 angiotensin II receptor
Species	Cavia porcellus (Guinea pig)
Gene	AGTR1
Synonym	Angiotensin II type-1 receptor AT1
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
UniProt	Q9WV26
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1671613
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	UNII-23B5RBZGBD
Molecular formula	C25H21N5O
IUPAC name	2-ethyl-4-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methoxy]quinoline
Molecular weight	407.477
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.3
Synonyms	2-Ethyl-4-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-quinoline CHEMBL284536 SCHEMBL2142522 23B5RBZGBD Ici D8731 ZD-8731 143494-72-8 BDBM50003387 L004793 2-Ethyl-4-[2''-(2H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-quinoline D 8731 ICI-D-8731 Zeneca ZD8731 2-Ethyl-4-((2'-(1H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl)methoxy)quinoline hydrochloride Quinoline, 2-ethyl-4-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methoxy)- 2-ethyl-4-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methoxy]quinoline D-8731 ZD 8731 AC1L317G Ici-D8731 [ Show all ]
Inchi Key	FSJCYXPMWQPVOS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H21N5O/c1-2-19-15-24(22-9-5-6-10-23(22)26-19)31-16-17-11-13-18(14-12-17)20-7-3-4-8-21(20)25-27-29-30-28-25/h3-15H,2,16H2,1H3,(H,27,28,29,30)
PubChem CID	132562
ChEMBL	CHEMBL284536
IUPHAR	N/A
BindingDB	50003387
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	30.0 nM	PMID8576904, PMID21071232	BindingDB,ChEMBL
IC50	31.0 nM	PMID1433210, PMID8487261	BindingDB,ChEMBL

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