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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	6711-46-2
Molecular formula	C10H16N2
IUPAC name	N',N'-dimethyl-N-phenylethane-1,2-diamine
Molecular weight	164.252
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	1.5
Synonyms	BDBM50404731 MCULE-7881736707 N-[2-(dimethylamino)ethyl]aniline dimethyl[2-(phenylamino)ethyl]amine n,n-dimethyl-n'-phenyl-1,2-ethanediamine SBB045223 AB01322874-02 AC1Q4TSK EN300-59495 N,N-dimethyl-N'-phenylethylenedi-amine Z1262253021 1,2-Ethanediamine, N,N-dimethyl-N'-phenyl- MolPort-004-400-370 NCGC00327599-01 AC1L30TX DTXSID1064459 N,N-dimethyl-N'-phenyl-ethylenediamine SCHEMBL171395 AKOS000253466 FRCVOKAWJJIJHQ-UHFFFAOYSA-N N,N-Dimethyl-N'-phenylethylenediamine ZINC2560537 1,2-Ethanediamine, N1,N1-dimethyl-N2-phenyl- CHEMBL138614 N',N'-dimethyl-N-phenylethane-1,2-diamine NE10755 A9098 AC1Q3WUG EINECS 229-760-3 N,N-dimethyl-N'-phenylethane-1,2-diamine STK832181 [ Show all ]
Inchi Key	FRCVOKAWJJIJHQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H16N2/c1-12(2)9-8-11-10-6-4-3-5-7-10/h3-7,11H,8-9H2,1-2H3
PubChem CID	81206
ChEMBL	CHEMBL138614
IUPHAR	N/A
BindingDB	50404731
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	954.99 nM	PMID7086824, PMID6581313	BindingDB,ChEMBL
Kd	955.0 nM	PMID6581313	BindingDB

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