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Name | Hydroxycarboxylic acid receptor 2 |
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Species | Homo sapiens (Human) |
Gene | HCAR2 |
Synonym | G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 [ Show all ] |
Disease | Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis [ Show all ] |
Length | 363 |
Amino acid sequence | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP |
UniProt | Q8TDS4 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q8TDS4 |
3D structure model | This predicted structure model is from GPCR-EXP Q8TDS4. |
BioLiP | N/A |
Therapeutic Target Database | T00864 |
ChEMBL | CHEMBL3785 |
IUPHAR | 312 |
DrugBank | BE0000635 |
Name | CHEMBL393064 |
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Molecular formula | C7H10N6 |
IUPAC name | 5-(5-propyl-1H-pyrazol-3-yl)-2H-tetrazole |
Molecular weight | 178.199 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 0.7 |
Synonyms | BDBM50220833 5-(5-propyl-1H-pyrazol-3-yl)-1H-tetrazole |
Inchi Key | FQGVBFKPIPPKKG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C7H10N6/c1-2-3-5-4-6(9-8-5)7-10-12-13-11-7/h4H,2-3H2,1H3,(H,8,9)(H,10,11,12,13) |
PubChem CID | 44433528 |
ChEMBL | CHEMBL393064 |
IUPHAR | N/A |
BindingDB | 50220833 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <1000.0 nM | PMID17804224 | ChEMBL |
EC50 | 7762.0 nM | PMID17804224 | BindingDB |
EC50 | 7762.47 nM | PMID17804224 | ChEMBL |
Efficacy | 95.0 % | PMID17804224 | ChEMBL |
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