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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Motilin receptor
Species	Homo sapiens (Human)
Gene	MLNR
Synonym	GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR motilin receptor MOT-R [ Show all ]
Disease	Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder Pain Dyspepsia Diarrhea Delayed gastric emptying; Gastroparesis Constipation Gastroparesis [ Show all ]
Length	412
Amino acid sequence	MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProt	O43193
Protein Data Bank	N/A
GPCR-HGmod model	O43193
3D structure model	This predicted structure model is from GPCR-EXP O43193.
BioLiP	N/A
Therapeutic Target Database	T62306
ChEMBL	CHEMBL2203
IUPHAR	297
DrugBank	BE0003521

Ligand

Name	CHEMBL210923
Molecular formula	C38H44N4O5
IUPAC name	N-benzyl-N-[3-[[3-(2-morpholin-4-ylethoxy)-N-(phenylcarbamoyl)anilino]methyl]cyclohexyl]furan-2-carboxamide
Molecular weight	636.793
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	5.9
Synonyms	rac-1-((3-(N-benzylfuran-2-carboxamido)cyclohexyl)methyl)-1-(3-(2-morpholinoethoxy)phenyl)-3-phenylurea BDBM50186114
Inchi Key	FOWBIQIEPIBKKC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C38H44N4O5/c43-37(36-18-9-22-47-36)41(28-30-10-3-1-4-11-30)33-15-7-12-31(26-33)29-42(38(44)39-32-13-5-2-6-14-32)34-16-8-17-35(27-34)46-25-21-40-19-23-45-24-20-40/h1-6,8-11,13-14,16-18,22,27,31,33H,7,12,15,19-21,23-26,28-29H2,(H,39,44)
PubChem CID	44413072
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50186114
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	656.0 nM	PMID16650762	BindingDB

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