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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

NameCHEMBL300476
Molecular formulaC14H19ClN2O2
IUPAC name2-piperidin-1-ylethyl N-(3-chlorophenyl)carbamate
Molecular weight282.768
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.0
Synonyms(3-Chloro-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester
AC1L4N66
2-piperidin-1-ylethyl N-(3-chlorophenyl)carbamate
BDBM50058178
Inchi KeyFOLXVTGCYNUNST-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H19ClN2O2/c15-12-5-4-6-13(11-12)16-14(18)19-10-9-17-7-2-1-3-8-17/h4-6,11H,1-3,7-10H2,(H,16,18)
PubChem CID209710
ChEMBLCHEMBL300476
IUPHARN/A
BindingDB50058178
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki60.8 nMPMID9171886BindingDB,ChEMBL

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