Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Prostaglandin F2-alpha receptor
Species	Bos taurus (Bovine)
Gene	PTGFR
Synonym	PGF receptor PGF2-alpha receptor Prostanoid FP receptor
Disease	N/A for non-human GPCRs
Length	362
Amino acid sequence	MSTNSSIQPVSPESELLSNTTCQLEEDLSISFSIIFMTVGILSNSLAIAILMKAYQRFRQKYKSSFLLLASALVITDFFGHLINGTIAVFVYASDKDWIYFDKSNILCSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPIFHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQASRTWCFYKTDEIKDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKVKFRSQQHRQGRSHHFEMVIQLLGIMCVSCICWSPFLVTMASIGMNIQDFKDSCERTLFTLRMATWNQILDPWVYILLRKAVLRNLYVCTRRCCGVHVISLHVWELSSIKDSLKVAAISDLPVTEKVTQQTST
UniProt	P37289
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4820
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	17-phenyl-trinor-PGE2
Molecular formula	C23H30O5
IUPAC name	(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
Molecular weight	386.488
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	2.8
Synonyms	1271AH 17-phenyl-omega-trinor-PGE2 17-phenyltrinorprostaglandin E2 BML2-B01 FA(23:5)(OH2,Ke,cyclo2) IDI1_033839 SR-01000946438 17-phenyl trinor PGE2 17-Phenyl-trinor-PGE..2.. CAS_38315-43-4 HMS1361E11 NCGC00161300-01 ZINC13815368 (5Z)-7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]-5-oxocyclopentyl}hept-5-enoic acid 17-phenyl-18,19,20-trinor-prostaglandin E2 17-phenyltrinor-PGE2 AC1NR1GD CL 116147 HMS3402E11 PGE2,17-Phenyl 17-Ph-omega-trinor-PGE2 17-phenyl-omega-trinor-prostaglandin E2 BRD-K90214371-001-02-0 FOBVMYJQWZOGGJ-XYRJXBATSA-N LMFA03010067 SR-01000946438-1 17-PHENYL TRINOR PROSTAGLANDIN E2 9-Oxo-11.alpha.,15S-dihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid CHEBI:87820 HMS1791E11 NCGC00161300-02 (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid 17-phenyl-omega-trinor PGE2 17-phenyltrinor-prostaglandin E2 BDBM82094 D0X2MQ HMS3648J13 SCHEMBL3367843 17-Ph-trinor-PGE2 17-phenyl-PGE2 38315-43-4 BSPBio_001369 GTPL1912 MolPort-027-640-885 Z-3298 17-phenyl-18,19,20-trinor-PGE2 17-phenyl-trinor-prostaglandin E2 9-oxo-11R,15S-dihydroxy-17-phenyl-18,19,20-trinor-5Z,13E-prostadienoic acid CHEMBL1879970 HMS1989E11 NCGC00161300-03 [ Show all ]
Inchi Key	FOBVMYJQWZOGGJ-XYRJXBATSA-N
Inchi ID	InChI=1S/C23H30O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-20,22,24,26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19+,20+,22+/m0/s1
PubChem CID	5283068
ChEMBL	N/A
IUPHAR	1912
BindingDB	82094
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1413.0 nM	PMID9694973	BindingDB

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417