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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Vasopressin V1a receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr1a
Synonym	AVPR AVPR V1a AVPR1 antidiuretic hormone receptor 1a V1A receptor V1aR Vascular/hepatic-type arginine vasopressin receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	424
Amino acid sequence	MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST
UniProt	P30560
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2868
IUPHAR	366
DrugBank	N/A

Ligand

Name	CHEMBL118595
Molecular formula	C23H20N2O2
IUPAC name	N-[3-(3,4-dihydro-2H-quinoline-1-carbonyl)phenyl]benzamide
Molecular weight	356.425
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.2
Synonyms	AKOS003299477 N-[3-(3,4-Dihydro-2H-quinoline-1-carbonyl)-phenyl]-benzamide ZINC1132687 N~1~-{3-[3,4-dihydro-1(2H)-quinolinylcarbonyl]phenyl}benzamide MLS001183905 ST50631373 BDBM50052905 N-[3-(3,4-dihydro-2H-quinoline-1-carbonyl)phenyl]benzamide HMS2840F12 phenyl-N-[3-(1,2,3,4-tetrahydroquinolylcarbonyl)phenyl]carboxamide AC1LPI1B MolPort-001-634-755 STK117611 N-[3-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)phenyl]benzamide MCULE-1057599461 SMR000502306 [ Show all ]
Inchi Key	FMHUWDDFCIGSCN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H20N2O2/c26-22(18-9-2-1-3-10-18)24-20-13-6-11-19(16-20)23(27)25-15-7-12-17-8-4-5-14-21(17)25/h1-6,8-11,13-14,16H,7,12,15H2,(H,24,26)
PubChem CID	1307424
ChEMBL	CHEMBL118595
IUPHAR	N/A
BindingDB	50052905
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<100000.0 nM	PMID8784453	BindingDB,ChEMBL

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