You can:
Name | Metabotropic glutamate receptor 3 |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Grm3 |
Synonym | mGluR3 mGlu3 receptor GPRC1C glutamate receptor |
Disease | N/A for non-human GPCRs |
Length | 879 |
Amino acid sequence | MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL |
UniProt | P31422 |
Protein Data Bank | 2e4u, 2e4v, 2e4w, 2e4x, 2e4y |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 2e4u. |
BioLiP | BL0086116,BL0086117, BL0086120,BL0086121, BL0086118,BL0086119, BL0086114,BL0086115, BL0086112,BL0086113 |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3067 |
IUPHAR | 291 |
DrugBank | N/A |
Name | CHEMBL538489 |
---|---|
Molecular formula | C14H18Cl2N2O6 |
IUPAC name | (2R,4R)-4-amino-1-[carboxy(phenyl)methyl]pyrrolidine-2,4-dicarboxylic acid;dihydrochloride |
Molecular weight | 381.206 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 6 |
XlogP | None |
Synonyms | N/A |
Inchi Key | FMDWFRCTYAUEII-XIQBYQNJSA-N |
Inchi ID | InChI=1S/C14H16N2O6.2ClH/c15-14(13(21)22)6-9(11(17)18)16(7-14)10(12(19)20)8-4-2-1-3-5-8;;/h1-5,9-10H,6-7,15H2,(H,17,18)(H,19,20)(H,21,22);2*1H/t9-,10?,14-;;/m1../s1 |
PubChem CID | 10091202 |
ChEMBL | CHEMBL538489 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 21000.0 nM | PMID11459661 | ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417