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GPCR

Name	Motilin receptor
Species	Homo sapiens (Human)
Gene	MLNR
Synonym	GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR motilin receptor MOT-R [ Show all ]
Disease	Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder Pain Dyspepsia Diarrhea Delayed gastric emptying; Gastroparesis Constipation Gastroparesis [ Show all ]
Length	412
Amino acid sequence	MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProt	O43193
Protein Data Bank	N/A
GPCR-HGmod model	O43193
3D structure model	This predicted structure model is from GPCR-EXP O43193.
BioLiP	N/A
Therapeutic Target Database	T62306
ChEMBL	CHEMBL2203
IUPHAR	297
DrugBank	BE0003521

Ligand

Name	CHEMBL296962
Molecular formula	C22H26N6O6
IUPAC name	N-[(2S)-1-amino-1-oxopropan-2-yl]-2-(1,3-benzodioxol-5-ylmethyl)-1,3-dioxospiro[8H-[1,2,4]triazolo[1,2-a]pyridazine-5,4'-piperidine]-8-carboxamide
Molecular weight	470.486
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	-0.2
Synonyms	8''N-[1-carbamoyl-(1S)-ethyl]-2''-benzo[d][1,3]dioxol-5-ylmethyl-1'',3''-dioxospiro[hexahydropyridine-4,5''-(2'',3'',5'',8''-tetrahydro-1''H-[1,2,4]triazolo[1,2-a]pyridazine)]-8''-carboxamide BDBM50143029
Inchi Key	ALCQOLFKKNMFCB-CFMCSPIPSA-N
Inchi ID	InChI=1S/C22H26N6O6/c1-13(18(23)29)25-19(30)15-4-5-22(6-8-24-9-7-22)28-21(32)26(20(31)27(15)28)11-14-2-3-16-17(10-14)34-12-33-16/h2-5,10,13,15,24H,6-9,11-12H2,1H3,(H2,23,29)(H,25,30)/t13-,15?/m0/s1
PubChem CID	11408794
ChEMBL	CHEMBL296962
IUPHAR	N/A
BindingDB	50143029
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID15027861	BindingDB,ChEMBL

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