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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptides B/W receptor type 1
Species	Homo sapiens (Human)
Gene	NPBWR1
Synonym	G protein-coupled receptor 7 G-protein coupled receptor 7 GPR7 neuropeptides B/W receptor type 1 NPBW1 receptor
Disease	N/A
Length	328
Amino acid sequence	MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProt	P48145
Protein Data Bank	N/A
GPCR-HGmod model	P48145
3D structure model	This predicted structure model is from GPCR-EXP P48145.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293293
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1973416
Molecular formula	C24H17ClN2O4
IUPAC name	5-chloro-4-(4-methoxyphenoxy)-2-(9H-xanthen-9-yl)pyridazin-3-one
Molecular weight	432.86
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.8
Synonyms	SR-02000001245 SR-02000001245-1 BDBM50425616
Inchi Key	FJEZSQVSLDYNAF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H17ClN2O4/c1-29-15-10-12-16(13-11-15)30-23-19(25)14-26-27(24(23)28)22-17-6-2-4-8-20(17)31-21-9-5-3-7-18(21)22/h2-14,22H,1H3
PubChem CID	53230285
ChEMBL	CHEMBL1973416
IUPHAR	N/A
BindingDB	50425616
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3100.0 nM	PMID23287738	BindingDB,ChEMBL
IC50	3110.0 nM	PubChem BioAssay data set	ChEMBL

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