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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Homo sapiens (Human)
Gene	HTR7
Synonym	5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 GPRFO 5-HT7 receptor 5-HTx 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [ Show all ]
Disease	Sleep disorders Schizophrenia Major depressive disorder
Length	479
Amino acid sequence	MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProt	P34969
Protein Data Bank	N/A
GPCR-HGmod model	P34969
3D structure model	This predicted structure model is from GPCR-EXP P34969.
BioLiP	N/A
Therapeutic Target Database	T79062
ChEMBL	CHEMBL3155
IUPHAR	12
DrugBank	BE0000650, BE0004862

Ligand

Name	CHEMBL493402
Molecular formula	C22H31N3O4S
IUPAC name	4-methoxy-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-2-yl]benzenesulfonamide
Molecular weight	433.567
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.3
Synonyms	4-Methoxy-N-{3-[4-(o-methoxyphenyl)-piperazin-1-yl]-1-methyl-propyl}-benzen sulfonamide BDBM50260645
Inchi Key	AKVGJPMPJJAWLP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H31N3O4S/c1-18(23-30(26,27)20-10-8-19(28-2)9-11-20)12-13-24-14-16-25(17-15-24)21-6-4-5-7-22(21)29-3/h4-11,18,23H,12-17H2,1-3H3
PubChem CID	42635389
ChEMBL	CHEMBL493402
IUPHAR	N/A
BindingDB	50260645
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	580.0 nM	PMID18456500	BindingDB,ChEMBL

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