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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL338977
Molecular formulaC38H65NO6S2
IUPAC name3-[6-[[4-(hexadecoxymethyl)oxolan-2-yl]methoxy]hexyl]-1,3-thiazol-3-ium;4-methylbenzenesulfonate
Molecular weight696.059
Hydrogen bond acceptor7
Hydrogen bond donor0
XlogPNone
SynonymsSCHEMBL9675366
Inchi KeyFHDAEYBXIKYDNG-UHFFFAOYSA-M
Inchi IDInChI=1S/C31H58NO3S.C7H8O3S/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-22-33-26-30-25-31(35-27-30)28-34-23-19-16-14-17-20-32-21-24-36-29-32;1-6-2-4-7(5-3-6)11(8,9)10/h21,24,29-31H,2-20,22-23,25-28H2,1H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
PubChem CID14785888
ChEMBLCHEMBL338977
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC50540.0 nMPMID1992139ChEMBL

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