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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptides B/W receptor type 1
Species	Homo sapiens (Human)
Gene	NPBWR1
Synonym	G protein-coupled receptor 7 G-protein coupled receptor 7 GPR7 neuropeptides B/W receptor type 1 NPBW1 receptor
Disease	N/A
Length	328
Amino acid sequence	MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProt	P48145
Protein Data Bank	N/A
GPCR-HGmod model	P48145
3D structure model	This predicted structure model is from GPCR-EXP P48145.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293293
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SR-02000000448
Molecular formula	C21H21ClN2O3
IUPAC name	5-chloro-4-(4-methoxyphenoxy)-2-(3-methyl-4-propan-2-ylphenyl)pyridazin-3-one
Molecular weight	384.86
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.1
Synonyms	MLS003170613 5-chloro-4-(4-methoxyphenoxy)-2-(3-methyl-4-propan-2-ylphenyl)-3-pyridazinone SR-02000000448-1 BDBM75918 CHEMBL1710711 5-chloranyl-4-(4-methoxyphenoxy)-2-(3-methyl-4-propan-2-yl-phenyl)pyridazin-3-one SMR001872588 5-chloro-4-(4-methoxyphenoxy)-2-(3-methyl-4-propan-2-ylphenyl)pyridazin-3-one CHEBI:92390 cid_46835808 5-chloro-2-(4-isopropyl-3-methyl-phenyl)-4-(4-methoxyphenoxy)pyridazin-3-one [ Show all ]
Inchi Key	FFXHAANGHHWSSY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H21ClN2O3/c1-13(2)18-10-5-15(11-14(18)3)24-21(25)20(19(22)12-23-24)27-17-8-6-16(26-4)7-9-17/h5-13H,1-4H3
PubChem CID	46835808
ChEMBL	CHEMBL1710711
IUPHAR	N/A
BindingDB	75918
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	299.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
IC50	300.0 nM	PMID23079522	BindingDB,ChEMBL

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