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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptides B/W receptor type 1
Species	Homo sapiens (Human)
Gene	NPBWR1
Synonym	G protein-coupled receptor 7 G-protein coupled receptor 7 GPR7 neuropeptides B/W receptor type 1 NPBW1 receptor
Disease	N/A
Length	328
Amino acid sequence	MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProt	P48145
Protein Data Bank	N/A
GPCR-HGmod model	P48145
3D structure model	This predicted structure model is from GPCR-EXP P48145.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293293
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SR-02000000483
Molecular formula	C18H15ClN2O4
IUPAC name	5-chloro-4-(4-methoxyphenoxy)-2-(3-methoxyphenyl)pyridazin-3-one
Molecular weight	358.778
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.5
Synonyms	5-chloranyl-4-(4-methoxyphenoxy)-2-(3-methoxyphenyl)pyridazin-3-one CHEMBL1700476 SR-02000000483-1 5-chloro-4-(4-methoxyphenoxy)-2-(3-methoxyphenyl)-3-pyridazinone BDBM75947 cid_46850891 5-chloro-4-(4-methoxyphenoxy)-2-(3-methoxyphenyl)pyridazin-3-one [ Show all ]
Inchi Key	AKNGGPYBXULRJE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H15ClN2O4/c1-23-13-6-8-14(9-7-13)25-17-16(19)11-20-21(18(17)22)12-4-3-5-15(10-12)24-2/h3-11H,1-2H3
PubChem CID	46850891
ChEMBL	CHEMBL1700476
IUPHAR	N/A
BindingDB	75947
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	410.0 nM	, PubChem BioAssay data set, PMID23079522	BindingDB,ChEMBL

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