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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(4) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd4
Synonym	D(2C) dopamine receptor D4 receptor D4R Dopamine D4 receptor dopamine receptor 4
Disease	N/A for non-human GPCRs
Length	387
Amino acid sequence	MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProt	P30729
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3361
IUPHAR	217
DrugBank	N/A

Ligand

Name	DL-Homocysteine
Molecular formula	C4H9NO2S
IUPAC name	2-amino-4-sulfanylbutanoic acid
Molecular weight	135.181
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	-3.4
Synonyms	ST51016083 2-amino-4-mercapto-Butanoic acid 454-28-4 AC1Q50C4 Butanoic acid, 2-amino-4-mercapto- CS-W021561 DL-Homocysteine, >=95% (titration) Homocysteine # LS-75890 NSC206252 184291-EP2269992A1 184291-EP2277865A1 USAF B-12 2-Amino-4-mercaptobutanoic acid 4CH-016196 AN-45000 Butyric acid, 2-amino-4-mercapto-, DL- (9CI) DB-020435 FFFHZYDWPBMWHY-UHFFFAOYSA-N HY-W040821 NSC 206252 PubChem19432 1C51025E-77A8-4D48-8DC1-692A15D7F9D4 2-amino-4-sulfanylbutanoate AB0011058 bmse000430 CHEBI:17230 homo-cys KSC491O8H NSC-43117 (S)-2-amino-4-mercapto-Butanoic acid SCHEMBL35836 TR-017265 2-amino-4-mercapto-DL-Butyrate 454-29-5 ACMC-1B2D6 Butyric acid, 2-amino-4-mercapto- CTK3J1783 DL-Homocysteine, analytical standard Homocysteine, dl- MCULE-8057550187 NSC43117 184291-EP2275102A1 184291-EP2277867A2 W-106139 2-Amino-4-mercaptobutyric acid 6681-97-6 ANW-30276 C05330 DL-2-amino-4-mercapto-Butyric acid FT-0625470 I04-0139 NSC-118376 (+-)-Homocysteine RTR-017265 ST24039929 2-amino-4-mercapto-Butanoate 2-amino-4-sulfanylbutanoic acid AC1L1A05 BRN 5493225 CHEMBL310604 DL-Homocysteine (free base) homocysteine L-2-amino-4-mercapto-Butyric acid NSC118376 TR-037238 2-amino-4-mercapto-DL-Butyric acid 454H295 AKOS009156824 Butyric acid, 2-amino-4-mercapto-, DL- D,L-Homocysteine EINECS 207-222-9 Homocysteine, L- MolPort-001-792-076 NSC_778 184291-EP2275404A1 184291-EP2280003A2 2-amino-4-sulfanyl-butanoic acid BDBM86202 CAS_778 DL-2-Amino-4-mercaptobutyric acid Hcy KB-50322 NSC-206252 (S)-2-amino-4-mercapto-Butanoate SC-50870 [ Show all ]
Inchi Key	FFFHZYDWPBMWHY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)
PubChem CID	778
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86202
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID12649361	BindingDB

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