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Name | Prostaglandin E2 receptor EP1 subtype |
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Species | Mus musculus (Mouse) |
Gene | Ptger1 |
Synonym | EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 405 |
Amino acid sequence | MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL |
UniProt | P35375 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2181 |
IUPHAR | 340 |
DrugBank | N/A |
Name | CHEMBL361098 |
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Molecular formula | C22H23NO5 |
IUPAC name | 1-(4-butoxybenzoyl)-5-methoxy-2-methylindole-3-carboxylic acid |
Molecular weight | 381.428 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 4.7 |
Synonyms | 1-(4-Butoxy-benzoyl)-5-methoxy-2-methyl-1H-indole-3-carboxylic acid BDBM50150967 |
Inchi Key | FFDFWESIOXOETM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H23NO5/c1-4-5-12-28-16-8-6-15(7-9-16)21(24)23-14(2)20(22(25)26)18-13-17(27-3)10-11-19(18)23/h6-11,13H,4-5,12H2,1-3H3,(H,25,26) |
PubChem CID | 11406401 |
ChEMBL | CHEMBL361098 |
IUPHAR | N/A |
BindingDB | 50150967 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | <10000.0 nM | PMID15357992 | BindingDB,ChEMBL |
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