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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Alpha-2A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2a
Synonym	CA2-47 alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2D adrenergic receptor Alpha-2AAR Alpha-2A adrenoreceptor Alpha-2A adrenoceptor adrenergic receptor Adrenergic alpha 2A receptor ADRA2R ADRA2 Adra-2a Adra-2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	450
Amino acid sequence	MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P22909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL327
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	7-iodo-1,2,3,4-tetrahydroisoquinoline
Molecular formula	C9H10IN
IUPAC name	7-iodo-1,2,3,4-tetrahydroisoquinoline
Molecular weight	259.09
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.2
Synonyms	7-IODO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE CHEMBL26828 tetrahydroisoquinoline (THIQ) deriv. 2 AC1NRBRZ DTXSID10415343 BDBM14060 Isoquinoline, 1,2,3,4-tetrahydro-7-iodo- CTK2H2629 ZINC12503940 AJ-62457 FT-0729135 1n7j SCHEMBL4330301 72299-62-8 DB03824 1,2,3,4-Tetrahydro-7-iodo-isoquinoline AKOS022182519 IDI [ Show all ]
Inchi Key	FFCFXJXBXUOFIU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H10IN/c10-9-2-1-7-3-4-11-6-8(7)5-9/h1-2,5,11H,3-4,6H2
PubChem CID	5288606
ChEMBL	CHEMBL26828
IUPHAR	N/A
BindingDB	14060
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	220.0 nM	PMID14695818	BindingDB,ChEMBL

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