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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS000709291
Molecular formula	C17H25N5O3
IUPAC name	N-[(E)-1-(4-hexoxy-3-nitrophenyl)ethylideneamino]-4,5-dihydro-1H-imidazol-2-amine
Molecular weight	347.419
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.0
Synonyms	MolPort-019-766-111 [1-(4-hexoxy-3-nitro-phenyl)ethylideneamino]-(2-imidazolin-2-yl)amine BDBM51841 SMR000289958 cid_3098372 ST50221950 AKOS000506246 N-[1-(4-hexoxy-3-nitro-phenyl)ethylideneamino]-4,5-dihydro-1H-imidazol-2-amine SR-01000367424 [(1E)-2-(4-hexyloxy-3-nitrophenyl)-1-azaprop-1-enyl]-2-imidazolin-2-ylamine BAS 00297129 N-[1-(4-hexoxy-3-nitrophenyl)ethylideneamino]-4,5-dihydro-1H-imidazol-2-amine CHEMBL3207463 SR-01000367424-1 [ Show all ]
Inchi Key	AKJVZFLOSQWOMV-DEDYPNTBSA-N
Inchi ID	InChI=1S/C17H25N5O3/c1-3-4-5-6-11-25-16-8-7-14(12-15(16)22(23)24)13(2)20-21-17-18-9-10-19-17/h7-8,12H,3-6,9-11H2,1-2H3,(H2,18,19,21)/b20-13+
PubChem CID	9590748
ChEMBL	CHEMBL3207463
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	4466.8 nM	PubChem BioAssay data set	ChEMBL

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