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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

NameCHEMBL57695
Molecular formulaC26H33N5O3
IUPAC namebenzyl N-[1-[2-[(1-propan-2-ylindazole-3-carbonyl)amino]ethyl]piperidin-4-yl]carbamate
Molecular weight463.582
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP3.7
SynonymsPDSP2_000068
BDBM85225
N-(2-(4-((Benzyloxycarbonyl)amino)-1-piperidinyl)-ethyl)-1-isopropylindazole-3-carboxamide Oxalate
SCHEMBL7387902
PDSP1_000068
Inchi KeyFEDKTGOMGVYEHB-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H33N5O3/c1-19(2)31-23-11-7-6-10-22(23)24(29-31)25(32)27-14-17-30-15-12-21(13-16-30)28-26(33)34-18-20-8-4-3-5-9-20/h3-11,19,21H,12-18H2,1-2H3,(H,27,32)(H,28,33)
PubChem CID11798310
ChEMBLCHEMBL57695
IUPHARN/A
BindingDB85225
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Relaxation2.8 %PMID9599243ChEMBL
Relaxation21.0 %PMID9599243ChEMBL

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