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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Rattus norvegicus (Rat)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProt	P46002
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4127
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL368657
Molecular formula	C30H29N5O4
IUPAC name	methyl 1-(dimethylcarbamoyl)-3-[4-[(2,4,6-trimethylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]indole-4-carboxylate
Molecular weight	523.593
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	4.3
Synonyms	1-Dimethylcarbamoyl-3-[4-(2,4,6-trimethyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzoyl]-1H-indole-4-carboxylic acid methyl ester BDBM50062111
Inchi Key	FDUNDGKXMVEOSP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H29N5O4/c1-17-14-25-27(18(2)31-17)32-19(3)34(25)15-20-10-12-21(13-11-20)28(36)23-16-35(30(38)33(4)5)24-9-7-8-22(26(23)24)29(37)39-6/h7-14,16H,15H2,1-6H3
PubChem CID	11800192
ChEMBL	CHEMBL368657
IUPHAR	N/A
BindingDB	50062111
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
ED50	<1.0 mg.kg-1	PMID9438024	ChEMBL

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