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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL198724
Molecular formula	C30H30Cl2N4O2
IUPAC name	N-[2-[4-(3-cyanophenyl)phenyl]propan-2-yl]-N-[2-(3,5-dichloroanilino)-2-oxoethyl]-2-pyrrolidin-1-ylacetamide
Molecular weight	549.496
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.9
Synonyms	BDBM50174826 N-[1-(3''-cyano-biphenyl-4-yl)-1-methyl-ethyl]-N-[(3,5-dichloro-phenylcarbamoyl)-methyl]-2-pyrrolidin-1-yl-acetamide
Inchi Key	AKGIRNJXSHNYDR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H30Cl2N4O2/c1-30(2,24-10-8-22(9-11-24)23-7-5-6-21(14-23)18-33)36(29(38)20-35-12-3-4-13-35)19-28(37)34-27-16-25(31)15-26(32)17-27/h5-11,14-17H,3-4,12-13,19-20H2,1-2H3,(H,34,37)
PubChem CID	10166088
ChEMBL	CHEMBL198724
IUPHAR	N/A
BindingDB	50174826
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	131.0 nM	PMID16202583	BindingDB,ChEMBL

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