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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Endothelin-1 receptor
Species	Rattus norvegicus (Rat)
Gene	Ednra
Synonym	endothelin A receptor Endothelin receptor type A {ECO:0000312\|RGD:2535} ENDOR endothelin-1 receptor ET-A ET-AR ETA receptor Gpcr10 [ Show all ]
Disease	N/A for non-human GPCRs
Length	426
Amino acid sequence	MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
UniProt	P26684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4566
IUPHAR	219
DrugBank	N/A

Ligand

Name	Sulfiodizole
Molecular formula	C10H10IN3O3S
IUPAC name	4-amino-N-(4-iodo-5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
Molecular weight	379.172
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	1.6
Synonyms	LS-147799 AC1L3QZM BDBM50091532 4-Iodo-5-methyl-3-sulfanilamidoisoxazole Sulfanilamide, N(sup 1)-(4-iodo-5-methyl-3-isoxazolyl)- AC1Q4PLV Benzenesulfonamide, 4-amino-N-(4-iodo-5-methyl-3-isoxazolyl)- 4-amino-n-(4-iodo-5-methyl-1,2-oxazol-3-yl)benzenesulfonamide CHEMBL298976 AKOS030586380 BRN 0808571 4-Amino-N-(4-iodo-5-methyl-isoxazol-3-yl)-benzenesulfonamide [ Show all ]
Inchi Key	FCLGWHGVNGNUQT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H10IN3O3S/c1-6-9(11)10(13-17-6)14-18(15,16)8-4-2-7(12)3-5-8/h2-5H,12H2,1H3,(H,13,14)
PubChem CID	120533
ChEMBL	CHEMBL298976
IUPHAR	N/A
BindingDB	50091532
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	11000.0 nM	PMID10969989	BindingDB,ChEMBL

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