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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Lutropin-choriogonadotropic hormone receptor
Species	Homo sapiens (Human)
Gene	LHCGR
Synonym	lutropin-choriogonadotropic hormone receptor Luteinizing hormone receptor LSH-R LHR LH/CG-R LH-R LH receptor LGR2 LCGR Choriogonadotropin receptor [ Show all ]
Disease	Heart disease Breast cancer Cancer Myelodysplastic syndrome Female infertility Fertility Leukemia Infertility [ Show all ]
Length	699
Amino acid sequence	MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
UniProt	P22888
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79473
ChEMBL	CHEMBL1854
IUPHAR	N/A
DrugBank	BE0000134

Ligand

Name	MLS000675932
Molecular formula	C16H12ClN3O3S
IUPAC name	5-chloro-2-methylsulfonyl-N-naphthalen-2-ylpyrimidine-4-carboxamide
Molecular weight	361.8
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.8
Synonyms	STK913227 5-chloro-2-methylsulfonyl-N-(2-naphthalenyl)-4-pyrimidinecarboxamide CHEMBL1480031 5-CHLORO-2-(METHYLSULFONYL)-N-(2-NAPHTHYL)-4-PYRIMIDINECARBOXAMIDE AC1Q4GKY MCULE-5416058210 5-chloro-2-mesyl-N-(2-naphthyl)pyrimidine-4-carboxamide BRD-K89789994-001-04-7 Oprea1_780451 Z56771875 325724-72-9 5-chloro-2-methylsulfonyl-N-naphthalen-2-ylpyrimidine-4-carboxamide cid_991251 5-chloro-2-(methylsulfonyl)-N-(naphthalen-2-yl)pyrimidine-4-carboxamide AKOS001017159 SMR000297158 5-chloro-2-methanesulfonyl-N-(naphthalen-2-yl)pyrimidine-4-carboxamide ZINC643945 5-chloranyl-2-methylsulfonyl-N-naphthalen-2-yl-pyrimidine-4-carboxamide AC1LKHDD HMS2620G05 5-chloro-2-(methylsulfonyl)-N-2-naphthyl-4-pyrimidinecarboxamide BDBM70951 MolPort-000-399-019 [ Show all ]
Inchi Key	FCEVPKDAWILUQM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H12ClN3O3S/c1-24(22,23)16-18-9-13(17)14(20-16)15(21)19-12-7-6-10-4-2-3-5-11(10)8-12/h2-9H,1H3,(H,19,21)
PubChem CID	991251
ChEMBL	CHEMBL1480031
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	75686.3 nM	PubChem BioAssay data set	ChEMBL

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