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GPCR

NameProstaglandin E2 receptor EP2 subtype
SpeciesRattus norvegicus (Rat)
GenePtger2
SynonymEP2 receptor
PGE receptor EP2 subtype
PGE2 receptor EP2 subtype
prostaglandin E receptor 2 (subtype EP2), 53kDa
Prostanoid EP2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length357
Amino acid sequenceMDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
UniProtQ62928
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4909
IUPHAR341
DrugBankN/A

Ligand

NameCHEMBL208411
Molecular formulaC30H33NO4
IUPAC name4-[3-[2-[3-hydroxy-4-(3-phenylphenyl)butyl]-5-oxopyrrolidin-1-yl]propyl]benzoic acid
Molecular weight471.597
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP5.4
Synonyms4-{3-[2-(4-biphenyl-3-yl-3-hydroxy-butyl)-5-oxo-pyrrolidin-1-yl]-propyl}-benzoic acid
BDBM50181291
SCHEMBL4991279
Inchi KeyFBSYWZQEXIMEQD-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H33NO4/c32-28(21-23-6-4-10-26(20-23)24-8-2-1-3-9-24)17-15-27-16-18-29(33)31(27)19-5-7-22-11-13-25(14-12-22)30(34)35/h1-4,6,8-14,20,27-28,32H,5,7,15-19,21H2,(H,34,35)
PubChem CID11351910
ChEMBLCHEMBL208411
IUPHARN/A
BindingDB50181291
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50<3200.0 nMPMID16442794BindingDB,ChEMBL

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