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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL367875
Molecular formula	C21H27N3OS
IUPAC name	6-(4-methylpiperazin-1-yl)-3-(propan-2-yloxymethyl)pyrrolo[2,1-b][1,3]benzothiazepine
Molecular weight	369.527
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.4
Synonyms	BDBM50137985 SCHEMBL6210142 1-Isopropoxymethyl-9-(4-methyl-piperazin-1-yl)-4-thia-10a-aza-benzo[f]azulene
Inchi Key	ABCRKPVZDDXKEX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H27N3OS/c1-16(2)25-15-17-8-9-21-24(17)14-19(23-12-10-22(3)11-13-23)18-6-4-5-7-20(18)26-21/h4-9,14,16H,10-13,15H2,1-3H3
PubChem CID	11222444
ChEMBL	CHEMBL367875
IUPHAR	N/A
BindingDB	50137985
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3824.0 nM	PMID14695828	BindingDB,ChEMBL

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