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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Motilin receptor
Species	Homo sapiens (Human)
Gene	MLNR
Synonym	GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR motilin receptor MOT-R [ Show all ]
Disease	Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder Pain Dyspepsia Diarrhea Delayed gastric emptying; Gastroparesis Constipation Gastroparesis [ Show all ]
Length	412
Amino acid sequence	MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProt	O43193
Protein Data Bank	N/A
GPCR-HGmod model	O43193
3D structure model	This predicted structure model is from GPCR-EXP O43193.
BioLiP	N/A
Therapeutic Target Database	T62306
ChEMBL	CHEMBL2203
IUPHAR	297
DrugBank	BE0003521

Ligand

Name	SCHEMBL2765637
Molecular formula	C25H28FN5O2
IUPAC name	6-(4-fluorophenoxy)-N-methyl-N-[4-methyl-5-[[(3S)-3-methylpiperazin-1-yl]methyl]pyridin-2-yl]pyridine-3-carboxamide
Molecular weight	449.53
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.1
Synonyms	CHEMBL2364321 6-[(4-Fluorophenyl)oxy]-N-methyl-N-(4-methyl-5-{[(3S)-3-methyl-1-piperazinyl]methyl}-2-pyridinyl)-3-pyridinecarboxamide FBILDSAANWEWAK-SFHVURJKSA-N
Inchi Key	FBILDSAANWEWAK-SFHVURJKSA-N
Inchi ID	InChI=1S/C25H28FN5O2/c1-17-12-23(28-14-20(17)16-31-11-10-27-18(2)15-31)30(3)25(32)19-4-9-24(29-13-19)33-22-7-5-21(26)6-8-22/h4-9,12-14,18,27H,10-11,15-16H2,1-3H3/t18-/m0/s1
PubChem CID	23728915
ChEMBL	CHEMBL2364321
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.995 nM	DOI: http://dx.doi.org/10.6019/CHEMBL2364262	ChEMBL

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