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GPCR

NameType-1B angiotensin II receptor
SpeciesRattus norvegicus (Rat)
GeneAgtr1b
SynonymAngiotensin II type-1B receptor
AT1B
AT3
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
UniProtP29089
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL263
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL312889
Molecular formulaC30H31N5O2
IUPAC name4-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-2-(propylamino)quinoline-3-carboxylic acid
Molecular weight493.611
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP7.1
SynonymsBDBM50145978
4-[4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-2-propylamino-quinoline-3-carboxylic acid
Inchi KeyFAXQYAWLPSPPSM-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H31N5O2/c1-5-15-31-28-26(30(36)37)25(22-9-7-8-10-23(22)33-28)21-13-11-20(12-14-21)17-35-24(6-2)34-27-18(3)16-19(4)32-29(27)35/h7-14,16H,5-6,15,17H2,1-4H3,(H,31,33)(H,36,37)
PubChem CID11352388
ChEMBLCHEMBL312889
IUPHARN/A
BindingDB50145978
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5066.0 nMPMID15115399BindingDB,ChEMBL

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