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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptides B/W receptor type 1
Species	Homo sapiens (Human)
Gene	NPBWR1
Synonym	G protein-coupled receptor 7 G-protein coupled receptor 7 GPR7 neuropeptides B/W receptor type 1 NPBW1 receptor
Disease	N/A
Length	328
Amino acid sequence	MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProt	P48145
Protein Data Bank	N/A
GPCR-HGmod model	P48145
3D structure model	This predicted structure model is from GPCR-EXP P48145.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293293
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SR-02000000364
Molecular formula	C16H11ClN2O3
IUPAC name	5-chloro-4-(4-hydroxyphenoxy)-2-phenylpyridazin-3-one
Molecular weight	314.725
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	5-chloro-4-(4-hydroxyphenoxy)-2-phenyl-pyridazin-3-one SR-02000000364-1 BDBM75893 5-chloranyl-4-(4-oxidanylphenoxy)-2-phenyl-pyridazin-3-one cid_46172933 5-chloro-4-(4-hydroxyphenoxy)-2-phenylpyridazin-3-one SR-02000000364-2 5-chloro-4-(4-hydroxyphenoxy)-2-phenyl-3-pyridazinone CHEMBL1729376 [ Show all ]
Inchi Key	FAXJCHPLHYTAOD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H11ClN2O3/c17-14-10-18-19(11-4-2-1-3-5-11)16(21)15(14)22-13-8-6-12(20)7-9-13/h1-10,20H
PubChem CID	46172933
ChEMBL	CHEMBL1729376
IUPHAR	N/A
BindingDB	75893
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2800.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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