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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
TaR-7b
Trace amine receptor 12
Trace amine receptor 7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701920
Molecular formulaC17H22N4O
IUPAC nameN-[4-[(2S)-morpholin-2-yl]phenyl]-5-propylpyrimidin-2-amine
Molecular weight298.39
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.4
SynonymsUS8802673, 21
BDBM129379
SCHEMBL12609662
Inchi KeyFAXHLOSHIRXFOH-MRXNPFEDSA-N
Inchi IDInChI=1S/C17H22N4O/c1-2-3-13-10-19-17(20-11-13)21-15-6-4-14(5-7-15)16-12-18-8-9-22-16/h4-7,10-11,16,18H,2-3,8-9,12H2,1H3,(H,19,20,21)/t16-/m1/s1
PubChem CID68325454
ChEMBLCHEMBL3701920
IUPHARN/A
BindingDB129379
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki24.5 nM, NoneBindingDB,ChEMBL

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