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Name | Trace amine-associated receptor 7b |
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Species | Rattus norvegicus (Rat) |
Gene | Taar7b |
Synonym | TaR-12 TaR-7b Trace amine receptor 12 Trace amine receptor 7b |
Disease | N/A for non-human GPCRs |
Length | 358 |
Amino acid sequence | MATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE |
UniProt | Q923X8 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2176813 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL3701991 |
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Molecular formula | C17H22N4O |
IUPAC name | N-[4-[(2R)-morpholin-2-yl]phenyl]-5-propylpyrimidin-2-amine |
Molecular weight | 298.39 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 2.4 |
Synonyms | US8802673, 93 BDBM129451 SCHEMBL12609950 |
Inchi Key | FAXHLOSHIRXFOH-INIZCTEOSA-N |
Inchi ID | InChI=1S/C17H22N4O/c1-2-3-13-10-19-17(20-11-13)21-15-6-4-14(5-7-15)16-12-18-8-9-22-16/h4-7,10-11,16,18H,2-3,8-9,12H2,1H3,(H,19,20,21)/t16-/m0/s1 |
PubChem CID | 68325676 |
ChEMBL | CHEMBL3701991 |
IUPHAR | N/A |
BindingDB | 129451 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 22.2 nM | , None | BindingDB,ChEMBL |
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