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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1B
Species	Homo sapiens (Human)
Gene	HTR1B
Synonym	5-HT1B receptor 5-HT-1B 5-HT-1D-beta 5-HT1B Serotonin 1D beta receptor HTR1D2 5-HT1B serotonin receptor 5-HT1DB 5-HT1Dbeta 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled serotonin receptor 1B S12 [ Show all ]
Disease	Chronic schizophrenics Major depressive disorder Migraine headaches Mood disorder Psychotic disorders Anxiety disorder [ Show all ]
Length	390
Amino acid sequence	MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
UniProt	P28222
Protein Data Bank	4iar, 6g79, 5v54
GPCR-HGmod model	P28222
3D structure model	This structure is from PDB ID 4iar.
BioLiP	BL0239857, BL0403524,BL0403525, BL0417722
Therapeutic Target Database	T07806
ChEMBL	CHEMBL1898
IUPHAR	2
DrugBank	BE0000797

Ligand

Name	pramipexole
Molecular formula	C10H17N3S
IUPAC name	(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
Molecular weight	211.327
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.9
Synonyms	HMS2051A21 KBio2_002340 (-) Pramipexole Mirapexin (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole NCGC00167441-03 104632-26-0 Pramipexole Teva 632P260 SC-46343 AB0055235 SpecPlus_000820 CAS-104632-26-0 SUD-919CL2Y CX1349 ZINC3781664 DSSTox_CID_3496 DTXSID6023496 HSDB 8253 KBioSS_002343 (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine MLS001423952 (S)-N 6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine Pramipexol [Spanish] 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (6S)- Pramipexolum A801025 Sifrol(TN) AK-55454 SR-01000763219 SY009549 DB-038042 FT-0651622 K-0425 Mirapex (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine NCGC00167441-01 (S)-Pramipexole Pramipexole (USAN/INN) 2-amino-6-propylaminotetrahydrobenzothiazole s2460 AB00053772_14 SND-919 BDBM50116766 ST24036373 CS-2510 U-98528E DivK1c_006916 HMS2090C15 KBio2_004908 (-)-Pramipexole Mirapexin (TN) (s)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole Oprymea 111GE001 Pramipexole [USAN:INN:BAN] 83619PEU5T SCHEMBL35376 AC1L3P1T Spectrum5_001453 CCG-100823 SUD919CL2Y D05575 DSSTox_GSID_23496 EC 600-593-1 HY-B0410 KS-00000A3W (6S)-N'-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine MolPort-003-849-957 (S)-N6-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (S)- Pramipexolum [Latin] AB00053772-12 SMR000449298 ANW-64032 SR-01000763219-5 CHEMBL301265 Tox21_112445 GTPL953 KBio1_001860 Mirapex (TN) (s)-(-)-2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole NCGC00167441-02 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperaziny Pramipexole Base SAM001247006 AB00053772_16 SND-919CL2Y BIDD:GT0250 SUD 919CL2Y CTK8C0068 UNII-83619PEU5T DS-14807 HMS2232B03 KBio2_007476 (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine MLS000758250 (S)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole;(S)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole Pramipexol 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)- Pramipexole [USAN:INN] Sifrol AJ-45593 Spectrum_001838 CHEBI:8356 SW197453-4 D0G8NN DSSTox_RID_77054 FASDKYOPVNHBLU-ZETCQYMHSA-N J-001211 LS-40722 (6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine NC00073 (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Pramipexole (Mirapex) 2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole RT-015572 AB00053772-13 SND 919 B1488 SR-01000763219-6 CPD000449298 Tox21_112445_1 DB00413 [ Show all ]
Inchi Key	FASDKYOPVNHBLU-ZETCQYMHSA-N
Inchi ID	InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1
PubChem CID	119570
ChEMBL	CHEMBL301265
IUPHAR	953
BindingDB	50116766
DrugBank	DB00413
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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