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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	FASDKYOPVNHBLU-UHFFFAOYSA-N
Molecular formula	C10H17N3S
IUPAC name	6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
Molecular weight	211.327
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.9
Synonyms	(+/-)2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole 6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine BEN629 I09-0213 N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine 104617-86-9 AC1Q4W5N CHEMBL76399 MolPort-006-395-737 T5932 (+/-)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole AN-5403 HMS3393A21 N6-Propyl-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine (Pramipexole, PPX) (S)-2-Amnio-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole A801038 Benzene,4-chloro-1-(trifluoromethoxy)-2-(trifluoromethyl)- L000492 N~6~-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride (+/-) 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole 2,6-benzothiazolediamine, 4,5,6,7-tetrahydro-n6-propyl- AKOS017258887 N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine TRA0068140 (+/-)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole BDBM50017550 HMS3657G15 N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine AC1L1J65 MCULE-4233228077 SCHEMBL195775 (+/-)-2-amino-6-(N-propylamino)-4,5,6,7-tetrahydrobenzothiazole 2,6-benzothiazolediamine, 4,5,6,7-tetrahydro-N~6~-propyl-, dihydrochloride ALBB-027263 HMS3370D06 N6-Propyl-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine VZ30192 [ Show all ]
Inchi Key	FASDKYOPVNHBLU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)
PubChem CID	4885
ChEMBL	CHEMBL76399
IUPHAR	N/A
BindingDB	50017550
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP

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