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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasopressin V2 receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr2
Synonym	AVPR V2 Antidiuretic hormone receptor ADHR Renal-type arginine vasopressin receptor V2 receptor V2R DIR3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	371
Amino acid sequence	MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProt	Q00788
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3766
IUPHAR	368
DrugBank	N/A

Ligand

Name	CHEMBL299440
Molecular formula	C28H26N4O5
IUPAC name	N-[5-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepine-5-carbonyl)pyridin-2-yl]-3,4,5-trimethoxybenzamide
Molecular weight	498.539
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.9
Synonyms	10-[6-(3,4,5-Trimethoxybenzoylamino)-3-pyridinylcarbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine SCHEMBL7388715
Inchi Key	FANVPLDNXWLTSP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H26N4O5/c1-35-23-13-20(14-24(36-2)26(23)37-3)27(33)30-25-11-10-18(15-29-25)28(34)32-17-21-8-6-12-31(21)16-19-7-4-5-9-22(19)32/h4-15H,16-17H2,1-3H3,(H,29,30,33)
PubChem CID	18917509
ChEMBL	CHEMBL299440
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	41.0 %	PMID10406633	ChEMBL

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