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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Somatostatin receptor type 2
Species	Rattus norvegicus (Rat)
Gene	Sstr2
Synonym	somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R SST2 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	369
Amino acid sequence	MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
UniProt	P30680
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2978
IUPHAR	356
DrugBank	N/A

Ligand

Name	CHEMBL250521
Molecular formula	C30H35N3O2
IUPAC name	[(3R,4aR,10aR)-6-methoxy-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-3-yl]-(4-naphthalen-1-ylpiperazin-1-yl)methanone
Molecular weight	469.629
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.0
Synonyms	BDBM50423370
Inchi Key	FABFUAOVAJIURP-PRVBGKCFSA-N
Inchi ID	InChI=1S/C30H35N3O2/c1-31-20-24(17-23-18-26-22(19-28(23)31)9-6-12-29(26)35-2)30(34)33-15-13-32(14-16-33)27-11-5-8-21-7-3-4-10-25(21)27/h3-12,23-24,28H,13-20H2,1-2H3/t23-,24-,28-/m1/s1
PubChem CID	44441876
ChEMBL	CHEMBL250521
IUPHAR	N/A
BindingDB	50423370
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	5495.0 nM	PMID17512199	BindingDB
Kd	5495.41 nM	PMID17512199	ChEMBL

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