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Name | Somatostatin receptor type 2 |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Sstr2 |
Synonym | somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 369 |
Amino acid sequence | MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI |
UniProt | P30680 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2978 |
IUPHAR | 356 |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
857 | CHEMBL399843 | C26H29F3N4O6S | 582.595 | 11 / 0 | 4.3 | No |
5067 | CHEMBL251335 | C24H30N4O | 390.531 | 4 / 0 | 3.0 | Yes |
5507 | CHEMBL460934 | C26H30N4O3 | 446.551 | 5 / 0 | 4.3 | Yes |
6803 | CHEMBL253653 | C25H28IN5O | 541.437 | 4 / 1 | 3.4 | No |
11125 | CHEMBL252032 | C25H26ClN7OS | 508.041 | 7 / 1 | 3.9 | No |
12115 | CHEMBL516837 | C31H36N4O3 | 512.654 | 5 / 0 | 5.2 | No |
12321 | CHEMBL251334 | C25H32N4O2 | 420.557 | 5 / 0 | 3.0 | Yes |
13369 | CHEMBL2011461 | C46H60N8O7 | 837.035 | 8 / 6 | 4.3 | No |
15959 | CHEMBL254500 | C26H30BrN5O2 | 524.463 | 4 / 1 | 3.1 | No |
15960 | CHEMBL252231 | C26H30BrN5O2 | 524.463 | 4 / 1 | 3.1 | No |
555547 | BDBM84629 | C71H81N11O9 | 1232.5 | 11 / 12 | 8.1 | No |
22096 | CHEMBL401091 | C26H29N5O3 | 459.55 | 6 / 0 | 3.3 | Yes |
22966 | CHEMBL248716 | C26H31BrN4O4 | 543.462 | 6 / 0 | 4.3 | No |
24864 | CHEMBL248717 | C27H34N4O4S | 510.653 | 7 / 0 | 4.1 | No |
28101 | CHEMBL398655 | C25H32N4O3 | 436.556 | 5 / 1 | 2.2 | Yes |
32620 | CHEMBL440962 | C29H34N4O2 | 470.617 | 5 / 0 | 4.3 | Yes |
35385 | CHEMBL251529 | C30H38N4O5 | 534.657 | 7 / 0 | 4.7 | No |
555628 | L-362855 | C57H70N10O8 | 1023.25 | 9 / 11 | 5.7 | No |
555630 | BDBM85012 | C52H68N12O13S2 | 1133.31 | 16 / 13 | 1.3 | No |
555631 | BDBM85011 | C52H68N12O13S2 | 1133.31 | 16 / 13 | 1.3 | No |
40767 | CHEMBL398681 | C26H32N4O4 | 464.566 | 6 / 0 | 3.6 | Yes |
42102 | CHEMBL251311 | C26H32FN3O2 | 437.559 | 5 / 0 | 3.8 | Yes |
46310 | CHEMBL249892 | C27H34N4O3 | 462.594 | 5 / 1 | 2.6 | Yes |
48331 | CHEMBL252002 | C24H26BrN5O | 480.41 | 4 / 2 | 3.2 | Yes |
51727 | CHEMBL254499 | C26H30ClN5O2 | 480.009 | 4 / 1 | 3.1 | Yes |
52388 | CHEMBL3144293 | C58H79IN10O17S3 | 1407.41 | 21 / 18 | 0.0 | No |
52390 | CHEMBL3144292 | C58H79IN10O17S3 | 1407.41 | 21 / 18 | 0.0 | No |
54301 | CHEMBL514027 | C31H36N4O3 | 512.654 | 5 / 0 | 5.4 | No |
56743 | CHEMBL400677 | C24H31N5O2 | 421.545 | 6 / 0 | 2.4 | Yes |
553526 | L 779976 | C33H43N7O3 | 585.753 | 4 / 5 | 3.4 | No |
555693 | Octreotide | C49H66N10O10S2 | 1019.25 | 14 / 13 | 1.0 | No |
553528 | Octreotide | C49H66N10O10S2 | 1019.25 | 14 / 13 | 1.0 | No |
61800 | CHEMBL3144282 | C67H95IN10O26S2 | 1643.57 | 30 / 24 | -4.4 | No |
62260 | CHEMBL250111 | C25H32N4O2 | 420.557 | 5 / 0 | 2.7 | Yes |
63619 | CHEMBL249894 | C27H32N3NaO4 | 485.56 | 6 / 0 | N/A | N/A |
68008 | CHEMBL250705 | C28H35N3O3 | 461.606 | 5 / 0 | 3.4 | Yes |
70045 | CHEMBL251110 | C25H30N4O2 | 418.541 | 5 / 0 | 2.3 | Yes |
71497 | CHEMBL250304 | C26H31F2N3O2 | 455.55 | 6 / 0 | 3.9 | Yes |
73235 | CHEMBL250521 | C30H35N3O2 | 469.629 | 4 / 0 | 5.0 | Yes |
74293 | CHEMBL460542 | C29H31F2N3O2 | 491.583 | 6 / 0 | 4.9 | Yes |
75964 | CHEMBL523814 | C29H32ClN5O2 | 518.058 | 6 / 1 | N/A | No |
80045 | CHEMBL253654 | C25H29N5O2 | 431.54 | 5 / 2 | 2.7 | Yes |
89005 | CHEMBL253232 | C25H29N5O | 415.541 | 4 / 1 | 2.7 | Yes |
89451 | CHEMBL251116 | C32H38N4O3 | 526.681 | 6 / 0 | 4.8 | No |
92138 | CHEMBL249111 | C27H32N6O3S | 520.652 | 9 / 0 | 2.9 | No |
555828 | BDBM82460 | C137H207N41O39S3 | 3148.59 | 48 / 44 | -16.0 | No |
553731 | Somatostatin 28 | C137H207N41O39S3 | 3148.59 | 48 / 46 | -15.2 | No |
99984 | CHEMBL401108 | C26H31N5O3S | 493.626 | 6 / 1 | 2.3 | Yes |
101076 | CHEMBL251751 | C30H38N4O6 | 550.656 | 8 / 0 | 4.7 | No |
101904 | CHEMBL398656 | C27H32N6O2 | 472.593 | 7 / 0 | 2.6 | Yes |
103287 | CHEMBL462157 | C28H31N5O3 | 485.588 | 5 / 0 | 4.2 | Yes |
104522 | CHEMBL539415 | C26H28BrClN4O | 527.891 | 3 / 1 | 5.1 | No |
106159 | CHEMBL249932 | C27H32N4O2 | 444.579 | 5 / 0 | 3.5 | Yes |
108134 | CHEMBL248715 | C25H30N6O2S | 478.615 | 8 / 0 | 3.2 | Yes |
108953 | CHEMBL251835 | C26H27BrN6O2 | 535.446 | 6 / 1 | 3.7 | No |
108959 | CHEMBL252232 | C26H27BrN6O2 | 535.446 | 6 / 1 | 3.7 | No |
109744 | CHEMBL3144288 | C49H65IN10O11S2 | 1159.14 | 15 / 14 | 1.3 | No |
109779 | CHEMBL440235 | C26H34N4O3 | 450.583 | 5 / 0 | 2.4 | Yes |
112067 | CHEMBL250912 | C27H31ClN2O2 | 451.007 | 3 / 0 | 4.6 | Yes |
115897 | CHEMBL254505 | C27H32BrN5O2 | 538.49 | 4 / 1 | 3.5 | No |
115943 | CHEMBL2011465 | C46H60N8O7 | 837.035 | 8 / 6 | 4.3 | No |
555934 | BIM 23052 | C61H75N11O10 | 1122.34 | 12 / 13 | 2.7 | No |
123171 | CHEMBL462335 | C29H32N4O3S | 516.66 | 6 / 0 | 5.0 | No |
124832 | CHEMBL251801 | C26H31N5O2S | 477.627 | 6 / 1 | 2.1 | Yes |
126613 | CHEMBL250314 | C26H31F3N4O5S | 568.612 | 11 / 0 | 3.8 | No |
127323 | CHEMBL517921 | C31H34N4O3 | 510.638 | 5 / 0 | 5.4 | No |
127718 | CHEMBL249930 | C27H32N4O2 | 444.579 | 5 / 0 | 3.5 | Yes |
128572 | CHEMBL250522 | C31H34N4O2 | 494.639 | 5 / 0 | 4.7 | Yes |
555994 | BDBM82254 | C41H60N10O9S2 | 901.112 | 13 / 14 | 0.0 | No |
133227 | CHEMBL400481 | C24H31N5O2 | 421.545 | 6 / 0 | 2.0 | Yes |
134606 | CHEMBL251754 | C25H27F3N6O4S2 | 596.644 | 13 / 0 | 4.0 | No |
135039 | CHEMBL251300 | C27H31N3O2 | 429.564 | 3 / 1 | 3.8 | Yes |
137632 | CHEMBL249112 | C26H32N4O4 | 464.566 | 6 / 0 | 3.6 | Yes |
137640 | Obelin | C26H32N4O4 | 464.566 | 6 / 0 | 3.6 | Yes |
142206 | CHEMBL440236 | C26H32N4O6S | 528.624 | 8 / 0 | 3.1 | No |
142938 | CHEMBL250723 | C30H36N4O2 | 484.644 | 5 / 0 | 4.4 | Yes |
144427 | CHEMBL250921 | C26H31N5O3 | 461.566 | 7 / 0 | 3.0 | Yes |
145341 | CHEMBL1076623 | C34H41F2N5O5S | 669.789 | 12 / 2 | N/A | No |
556044 | BIM-23023 | C49H65N11O10S2 | 1032.25 | 14 / 13 | 0.8 | No |
556062 | BIM 23268 | C54H67N11O9S2 | 1078.32 | 13 / 12 | 2.8 | No |
155583 | CHEMBL253438 | C25H28BrN5O | 494.437 | 4 / 1 | 3.7 | Yes |
155758 | CHEMBL2011463 | C45H58N8O7 | 823.008 | 8 / 7 | 4.1 | No |
158430 | CHEMBL252428 | C26H27ClF2N4O | 484.976 | 5 / 1 | 4.6 | Yes |
163378 | CHEMBL252029 | C26H29N5O3 | 459.55 | 5 / 1 | 3.3 | Yes |
163790 | CHEMBL250498 | C26H32N4O4 | 464.566 | 6 / 0 | 3.6 | Yes |
166602 | CHEMBL250098 | C27H35N3O4S | 497.654 | 6 / 0 | 3.0 | Yes |
170583 | CHEMBL254288 | C26H31N5O2 | 445.567 | 4 / 1 | 2.1 | Yes |
175220 | CHEMBL250305 | C27H31N5O4 | 489.576 | 7 / 0 | 3.3 | Yes |
175937 | CHEMBL251753 | C31H34N6O4S2 | 618.771 | 10 / 0 | 4.7 | No |
556217 | BDBM85230 | C54H69N11O9S2 | 1080.33 | 13 / 14 | 2.3 | No |
195432 | CHEMBL251301 | C20H29N3O2 | 343.471 | 4 / 1 | 1.5 | Yes |
195866 | CHEMBL251111 | C28H34N4O3 | 474.605 | 4 / 1 | 3.2 | Yes |
197343 | CHEMBL250724 | C29H34N4O2 | 470.617 | 5 / 0 | 4.3 | Yes |
205030 | CHEMBL3144291 | C67H93IN10O27S2 | 1657.55 | 31 / 24 | -6.4 | No |
206830 | CHEMBL473763 | C29H32ClF2N3O | 512.042 | 5 / 1 | N/A | No |
210153 | CHEMBL400136 | C27H31FN4O2 | 462.569 | 6 / 0 | 3.6 | Yes |
210208 | CHEMBL401131 | C26H28Cl2N4O | 483.437 | 3 / 1 | 5.0 | Yes |
211597 | CHEMBL399464 | C31H34N6O2S | 554.713 | 8 / 0 | 4.7 | No |
556324 | BDBM82255 | C57H69N11O8S2 | 1100.37 | 13 / 12 | 3.7 | No |
215818 | CHEMBL251752 | C27H32N4O4 | 476.577 | 6 / 0 | 3.3 | Yes |
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