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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Somatostatin receptor type 2
Species	Rattus norvegicus (Rat)
Gene	Sstr2
Synonym	somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R SST2 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	369
Amino acid sequence	MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
UniProt	P30680
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2978
IUPHAR	356
DrugBank	N/A

Ligand

Name	CHEMBL250921
Molecular formula	C26H31N5O3
IUPAC name	[(3R,4aR,10aR)-6-methoxy-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-3-yl]-[4-(2,1,3-benzoxadiazol-4-yl)piperazin-1-yl]methanone
Molecular weight	461.566
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.0
Synonyms	BDBM50423335
Inchi Key	IXYSHRRKNGKTJW-DNVFCKCGSA-N
Inchi ID	InChI=1S/C26H31N5O3/c1-29-16-19(13-18-14-20-17(15-23(18)29)5-3-8-24(20)33-2)26(32)31-11-9-30(10-12-31)22-7-4-6-21-25(22)28-34-27-21/h3-8,18-19,23H,9-16H2,1-2H3/t18-,19-,23-/m1/s1
PubChem CID	44441883
ChEMBL	CHEMBL250921
IUPHAR	N/A
BindingDB	50423335
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	3630.78 nM	PMID17512199	ChEMBL
Kd	3631.0 nM	PMID17512199	BindingDB

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