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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Galanin receptor type 1
Species	Homo sapiens (Human)
Gene	GALR1
Synonym	GAL1-R GALNR GALNR1 GALR-1 GAL1 receptor
Disease	Epileptic seizures
Length	349
Amino acid sequence	MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
UniProt	P47211
Protein Data Bank	N/A
GPCR-HGmod model	P47211
3D structure model	This predicted structure model is from GPCR-EXP P47211.
BioLiP	N/A
Therapeutic Target Database	T78581
ChEMBL	CHEMBL4894
IUPHAR	243
DrugBank	N/A

Ligand

Name	CHEMBL1921996
Molecular formula	C24H27F2N5O2
IUPAC name	2-N-cyclohexyl-4-N-[3-(difluoromethoxy)phenyl]-6-N-(4-methoxyphenyl)pyrimidine-2,4,6-triamine
Molecular weight	455.51
Hydrogen bond acceptor	9
Hydrogen bond donor	3
XlogP	7.0
Synonyms	BDBM50358655 SCHEMBL10144344
Inchi Key	DZPPHFUVZBBKLH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H27F2N5O2/c1-32-19-12-10-17(11-13-19)27-21-15-22(28-18-8-5-9-20(14-18)33-23(25)26)31-24(30-21)29-16-6-3-2-4-7-16/h5,8-16,23H,2-4,6-7H2,1H3,(H3,27,28,29,30,31)
PubChem CID	57401221
ChEMBL	CHEMBL1921996
IUPHAR	N/A
BindingDB	50358655
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5030.0 nM	PMID22018787	BindingDB,ChEMBL
Inhibition	60.0 %	PMID22018787	ChEMBL

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