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GLASS

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GPCR

Name	D(2) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD2
Synonym	dopamine receptor 2 Dopamine D2 receptor D2R D2A and D_2B D2(415) and D₂₍₄₄₄₎ D2 receptor [ Show all ]
Disease	Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease Inflammatory bowel disease Idiopathic thrombocytopenic purpura Hypertension; Angina pectoris Hypertension Hyperprolactinemia Huntington's disease Glaucoma Gastrointestinal problems Malignant phaeochromocytoma; Benign prostatic hypertrophy; Malignant essential hypertension Migraine headaches Nasal congestion Sexual dysfunction Schizophrenia; Schizoaffective disorders Schizophrenia; Bipolar disorder Schizophrenia Psychotic disorders Psychosis Postpartum haemorrhage Peripheral vasoconstriction; Pulmonary hypertension Parkinson's disease Pain; Inflammatory diseases Ophthalmic disease Non-small cell lung cancer Nausea; Vomiting Fibrosis False perceptions; Bipolar disorder Emesis Chronic obstructive pulmonary disease Cerebrovascular ischaemia Cardiotonic Cardiac failure Bacterial infections Breast cancer Bipolar disorder; Schizophrenia Bipolar disorder Corneal vascularity; Hyperaemia; Itching Asthma; Bronchitis Anxiety disorder Carcinoid syndrome; Acromegaly Advanced stage Parkinson's disease Dermal necrosis Depressive fatigue Alcohol use disorders Allergy Alzheimer disease Hypotension [ Show all ]
Length	443
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	P14416
Protein Data Bank	6cm4, 6c38
GPCR-HGmod model	P14416
3D structure model	This structure is from PDB ID 6cm4.
BioLiP	BL0408379, BL0403379
Therapeutic Target Database	T67162
ChEMBL	CHEMBL217
IUPHAR	215
DrugBank	BE0000756

Ligand

Name	tyramine
Molecular formula	C8H11NO
IUPAC name	4-(2-aminoethyl)phenol
Molecular weight	137.182
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.1
Synonyms	p-hydroxy-phenylethylamine RTC-060462 Spectrum3_000693 STK531130 Tox21_110282 Tyramine, 98%, FG Uteramine LS-103895 AC1Q54AZ NCGC00016011-01 AM20060645 NCGC00016011-09 beta-(4-Hydroxyphenyl)ethylamine NCGC00063825-06 BR-47332 Oprea1_294339 DivK1c_000918 2-(4-hydroxy-phenyl)ethylamine GTPL2148 21758-EP2298312A1 IDI1_000918 4-13-00-01788 (Beilstein Handbook Reference) KBio3_001665 4-Hydroxyphenylethylamine p-Tyramine SGCUT00017 Spectrum_001213 T-8910 TRA0098101 Tyramine, free base ZINC2233 a-(4-Hydroxyphenyl)-b-aminoethane MCULE-3986856320 AJ-08146 NCGC00016011-04 AS-11671 NCGC00016011-12 Biomol-NT_000075 NINDS_000918 BSPBio_002445 p-.beta.-Aminoethylphenol CS-W007606 DSSTox_RID_80079 2-(4-Hydroxyphenyl)ethylamine HMS2235J05 4- (2-aminoethyl)-Phenol KB-62189 4-Hydroxy-.beta.-phenylethylamine KS-00000NMU p-Hydroxy-beta-phenethylamine Phenol, 4-(2-aminoethyl)- SPECTRUM210400 ST24033343 Tenosin-wirkstoff Tyramine base Tyrosamine Lopac-T-2879 AB0010532 MLS000079096 alpha-(4-Hydroxyphenyl)-beta-aminoethane NCGC00016011-07 BDBM29135 NCGC00063825-04 bmse000891 NSC249188 CCG-39684 p-Hydroxy-.beta.-phenylethylamine D0C5RZ .beta.-(4-Hydroxyphenyl)ethylamine EINECS 200-115-8 HY-W007606 4-(2-Aminoethyl)-phenol(thyramin) KBio2_004261 4-Hydroxy-beta-phenylethylamine p-Hydroxyphenethylamine SC-15191 Spectrum4_001801 SY002127 Tox21_110282_1 Tyramine, 99% WLN: Z2R DQ LS-103913 ACMC-1AQH1 NCGC00016011-02 AN-41614 NCGC00016011-10 beta-Hydroxyphenylethylamine NCGC00063825-07 BRD-K53893978-001-03-1 p-(2-aminoethyl)-Phenol CHEMBL11608 DSSTox_CID_23874 2-(4-Hydroxyphenyl)-ethylamine GTPL2150 21758-EP2314571A2 InChI=1/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H 4-aminoethylphenol KBioGR_002405 51-67-2 [3H]-Tyramine P-hydroxy-b-phenethylamine para-Tyramine SMR000059295 SR-01000075365 T-8911 Tyramin Tyramine, Vetec(TM) reagent grade, 99% A0302 MFCD00008193 AK-47332 NCGC00016011-05 b-(4-Hydroxyphenyl)ethylamine NCGC00016011-14 bmse000243 NSC 249188 C00483 p-beta-Aminoethylphenol CTK1G9434 (4-hydroxyphenyl)ethylamine DTXSID2043874 2-(p-Hydroxyphenyl)ethylamine HMS502N20 4-(2-amino-ethyl)-phenol KBio1_000918 4-Hydroxy-b-phenylethylamine KSC269I3J p-Hydroxy-beta-phenylethylamine Phenol, p-(2-aminoethyl)- Spectrum2_000738 ST51037693 Tocosine Tyramine, 97% UNII-X8ZC7V0OX3 Lopac0_001136 AC1L1KQE MolPort-000-698-914 alpha.-(4-Hydroxyphenyl)-beta-aminoethane NCGC00016011-08 Benzeneethanamine, 4-hydroxy- NCGC00063825-05 BPBio1_001394 Opera_ID_887 CHEBI:15760 DB08841 2-(4'-Hydroxyphenyl)ethylamine FT-0651978 21758-EP2281563A1 I01-2032 4-(2-Aminoethyl)phenol KBio2_006829 4-Hydroxyphenethylamine p-Hydroxyphenylethylamine SCHEMBL4111 Spectrum5_000501 Systogene to_000085 Tyramine, analytical standard X8ZC7V0OX3 51T672 M-3365 AEF NCGC00016011-03 ANW-31318 NCGC00016011-11 BIDD:ER0507 NCGC00063825-08 BRN 1099914 p-(2-Aminoethyl)phenol cid_5610 DSSTox_GSID_43874 2-(4-hydroxyphenyl)ethanamine HMS1923C19 KB-204477 4-Hydroxy phenylethylamine KBioSS_001693 [3H]tyramine P-hydroxy-b-phenylethylamine Phenethylamine, p-hydroxy- SPBio_000696 SR-01000075365-5 TC-060462 Tyramine;4-(2-Amino-ethyl)-phenol AB00051887-15 MFCD00149002 AKOS000156022 NCGC00016011-06 BBL027695 NCGC00016011-16 bmse000870 NSC-249188 CAS-51-67-2 p-Hydroxy-.beta.-phenethylamine D01VFT .alpha.-(4-Hydroxyphenyl)-.beta.-aminoethane DZGWFCGJZKJUFP-UHFFFAOYSA-N HSDB 2132 4-(2-aminoethyl)-Phenol KBio2_001693 4-hydroxy-Benzeneethanamine L-Tyramine [ Show all ]
Inchi Key	DZGWFCGJZKJUFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
PubChem CID	5610
ChEMBL	CHEMBL11608
IUPHAR	2150, 2148
BindingDB	29135
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<17000.0 nM	Bioorg. Med. Chem. Lett., (1997) 7:9:1207,	BindingDB,ChEMBL
Ki	160000.0 nM	PMID9784114	BindingDB,ChEMBL

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