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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Homo sapiens (Human)
Gene	CHRM2
Synonym	cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 cholinergic receptor, muscarinic 2, cardiac cholinergic receptor, muscarinic 2 [ Show all ]
Disease	Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer Stabilize muscle contractions Unspecified Cardiovascular disorder Asthma Alzheimer disease [ Show all ]
Length	466
Amino acid sequence	MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P08172
Protein Data Bank	5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8
GPCR-HGmod model	P08172
3D structure model	This structure is from PDB ID 5zkc.
BioLiP	BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338
Therapeutic Target Database	T46185
ChEMBL	CHEMBL211
IUPHAR	14
DrugBank	BE0000560

Ligand

Name	13474-65-2
Molecular formula	C13H16N2O2
IUPAC name	2-[3-(dimethylamino)propyl]isoindole-1,3-dione
Molecular weight	232.283
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	1.9
Synonyms	1H-Isoindole-1,3(2H)-dione, 2-[3-(dimethylamino)propyl]- DYZHJGYWAJRDAJ-UHFFFAOYSA-N AKOS022231485 SCHEMBL1569149 CTK0F4329 2-[3-(dimethylamino)propyl]-1,3-isoindolinedione N-(dimethylaminopropyl)phthalimide ZINC26980456 DTXSID30504344 2-[3-(Dimethylamino)propyl]-1H-isoindole-1,3(2H)-dione N-[3-(Dimethylamino)propyl]phthalimide CHEMBL324165 [ Show all ]
Inchi Key	DYZHJGYWAJRDAJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H16N2O2/c1-14(2)8-5-9-15-12(16)10-6-3-4-7-11(10)13(15)17/h3-4,6-7H,5,8-9H2,1-2H3
PubChem CID	12612168
ChEMBL	CHEMBL324165
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Emax,diss	78.0 %	PMID15163212	ChEMBL
Emax,diss	100.0 %	PMID15163212	ChEMBL
Palpha	-1.15 -	PMID15163212	ChEMBL
Palpha	-0.26 -	PMID15163212	ChEMBL
pEC0.5,diss	4.51 -	PMID15163212	ChEMBL
pEC0.5,diss	5.89 -	PMID15163212	ChEMBL
pKA	6.0 -	PMID15163212	ChEMBL
pKA	6.53 -	PMID15163212	ChEMBL

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