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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Homo sapiens (Human)
Gene	HTR7
Synonym	5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 GPRFO 5-HT7 receptor 5-HTx 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [ Show all ]
Disease	Sleep disorders Schizophrenia Major depressive disorder
Length	479
Amino acid sequence	MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProt	P34969
Protein Data Bank	N/A
GPCR-HGmod model	P34969
3D structure model	This predicted structure model is from GPCR-EXP P34969.
BioLiP	N/A
Therapeutic Target Database	T79062
ChEMBL	CHEMBL3155
IUPHAR	12
DrugBank	BE0000650, BE0004862

Ligand

Name	CHEMBL2037529
Molecular formula	C20H23N5OS
IUPAC name	1-(1,3-benzothiazol-2-yl)-5-(4-pyrimidin-2-ylpiperazin-1-yl)pentan-1-one
Molecular weight	381.498
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.3
Synonyms	BDBM50384965
Inchi Key	DYFDYWXRTZSUEM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H23N5OS/c26-17(19-23-16-6-1-2-8-18(16)27-19)7-3-4-11-24-12-14-25(15-13-24)20-21-9-5-10-22-20/h1-2,5-6,8-10H,3-4,7,11-15H2
PubChem CID	60165411
ChEMBL	CHEMBL2037529
IUPHAR	N/A
BindingDB	50384965
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	337.0 nM	PMID22520153	BindingDB,ChEMBL

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