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GPCR

NameAlpha-1A adrenergic receptor
SpeciesBos taurus (Bovine)
GeneADRA1A
SynonymAlpha-1A adrenoceptor
Alpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTLHAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACTTARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
UniProtP18130
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4892
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL17926
Molecular formulaC11H13ClN2
IUPAC name3-chloro-2-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)pyridine
Molecular weight208.689
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP1.7
Synonyms3-Chloro-1''-methyl-1'',2'',3'',6''-tetrahydro-[2,4'']bipyridinyl
BDBM50026637
Inchi KeyDYEVMJXVMZRRPM-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H13ClN2/c1-14-7-4-9(5-8-14)11-10(12)3-2-6-13-11/h2-4,6H,5,7-8H2,1H3
PubChem CID44271903
ChEMBLCHEMBL17926
IUPHARN/A
BindingDB50026637
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2260.0 nMPMID6088770BindingDB,ChEMBL

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