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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL176678
Molecular formulaC30H31FN6O2
IUPAC name6-(4-fluorophenyl)-N,N-dimethyl-3-[2-[methyl-[3-(2-methylimidazo[4,5-c]pyridin-1-yl)propyl]amino]acetyl]indole-1-carboxamide
Molecular weight526.616
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP4.2
Synonyms6-(4-Fluoro-phenyl)-3-(2-{methyl-[3-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-propyl]-amino}-acetyl)-indole-1-carboxylic acid dimethylamide
BDBM50062097
SCHEMBL7497046
Inchi KeyDXPVOWOBYAJNOR-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H31FN6O2/c1-20-33-26-17-32-13-12-27(26)36(20)15-5-14-35(4)19-29(38)25-18-37(30(39)34(2)3)28-16-22(8-11-24(25)28)21-6-9-23(31)10-7-21/h6-13,16-18H,5,14-15,19H2,1-4H3
PubChem CID10625951
ChEMBLCHEMBL176678
IUPHARN/A
BindingDB50062097
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki140.0 nMPMID9438024BindingDB,ChEMBL

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