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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	SR-02000000351
Molecular formula	C18H12ClF3N2O2
IUPAC name	5-chloro-2-(4-methylphenyl)-4-[4-(trifluoromethyl)phenoxy]pyridazin-3-one
Molecular weight	380.751
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	4.9
Synonyms	CHEMBL1698879 SR-02000000351-1 5-chloro-2-(4-methylphenyl)-4-[4-(trifluoromethyl)phenoxy]pyridazin-3-one BDBM75883 cid_46172942 5-chloranyl-2-(4-methylphenyl)-4-[4-(trifluoromethyl)phenoxy]pyridazin-3-one SR-02000000351-2 5-chloro-2-(p-tolyl)-4-[4-(trifluoromethyl)phenoxy]pyridazin-3-one 5-chloro-2-(4-methylphenyl)-4-[4-(trifluoromethyl)phenoxy]-3-pyridazinone [ Show all ]
Inchi Key	DWXDDJWWZYYTMI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H12ClF3N2O2/c1-11-2-6-13(7-3-11)24-17(25)16(15(19)10-23-24)26-14-8-4-12(5-9-14)18(20,21)22/h2-10H,1H3
PubChem CID	46172942
ChEMBL	CHEMBL1698879
IUPHAR	N/A
BindingDB	75883
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5500.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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