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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Endothelin-1 receptor
Species	Rattus norvegicus (Rat)
Gene	Ednra
Synonym	endothelin A receptor Endothelin receptor type A {ECO:0000312\|RGD:2535} ENDOR endothelin-1 receptor ET-A ET-AR ETA receptor Gpcr10 [ Show all ]
Disease	N/A for non-human GPCRs
Length	426
Amino acid sequence	MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
UniProt	P26684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4566
IUPHAR	219
DrugBank	N/A

Ligand

Name	CHEMBL92353
Molecular formula	C24H22N2O4
IUPAC name	(4R)-4-[2-cyano-5-(pyridin-4-ylmethoxy)phenoxy]-4-(2-methylphenyl)butanoic acid
Molecular weight	402.45
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.8
Synonyms	(R)-4-[2-Cyano-5-(4-pyridylmethoxy)phenoxy]-4-(2-methylphenyl)butyric acid BDBM50065515 (R)-4-[2-Cyano-5-(pyridin-4-ylmethoxy)-phenoxy]-4-o-tolyl-butyric acid
Inchi Key	DWRDDFDMTNOIAR-JOCHJYFZSA-N
Inchi ID	InChI=1S/C24H22N2O4/c1-17-4-2-3-5-21(17)22(8-9-24(27)28)30-23-14-20(7-6-19(23)15-25)29-16-18-10-12-26-13-11-18/h2-7,10-14,22H,8-9,16H2,1H3,(H,27,28)/t22-/m1/s1
PubChem CID	10668808
ChEMBL	CHEMBL92353
IUPHAR	N/A
BindingDB	50065515
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	20.0 nM	PMID9667964	BindingDB,ChEMBL

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