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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL215279
Molecular formula	C29H33N3O3
IUPAC name	4-(3,4-dimethylphenoxy)-3-[(2-phenylacetyl)amino]-N-(2-pyrrolidin-1-ylethyl)benzamide
Molecular weight	471.601
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.8
Synonyms	BDBM50192524 SCHEMBL5148613 4-(3,4-dimethylphenoxy)-3-(2-phenylacetamido)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide
Inchi Key	DWQLOSQJDHUBFO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H33N3O3/c1-21-10-12-25(18-22(21)2)35-27-13-11-24(29(34)30-14-17-32-15-6-7-16-32)20-26(27)31-28(33)19-23-8-4-3-5-9-23/h3-5,8-13,18,20H,6-7,14-17,19H2,1-2H3,(H,30,34)(H,31,33)
PubChem CID	11655790
ChEMBL	CHEMBL215279
IUPHAR	N/A
BindingDB	50192524
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1000.0 nM	PMID16887348	BindingDB,ChEMBL

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