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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 4
Species	Rattus norvegicus (Rat)
Gene	Grm4
Synonym	glutamate receptor GPRC1D mGlu4 receptor mGluR4
Disease	N/A for non-human GPCRs
Length	912
Amino acid sequence	MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI
UniProt	P31423
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2787
IUPHAR	292
DrugBank	N/A

Ligand

Name	CHEMBL541754
Molecular formula	C13H10F2N2O2
IUPAC name	N-[3-(difluoromethoxy)phenyl]pyridine-2-carboxamide
Molecular weight	264.232
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.9
Synonyms	cid_44189740 N-(3-(difluoromethoxy)phenyl)picolinamide VU0361741-1 BDBM50293720
Inchi Key	DVMQKRGCWAAYQR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H10F2N2O2/c14-13(15)19-10-5-3-4-9(8-10)17-12(18)11-6-1-2-7-16-11/h1-8,13H,(H,17,18)
PubChem CID	44189740
ChEMBL	CHEMBL541754
IUPHAR	N/A
BindingDB	50293720
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	78.3 nM	PubChem BioAssay data set	ChEMBL
EC50	80.0 nM	PMID26231155, PMID19469556	BindingDB,ChEMBL
Emax	113.0 %	PMID19469556	ChEMBL
FC	44.4 -	PMID19469556	ChEMBL
IC50	9.9 nM	PMID25330258	BindingDB,ChEMBL
IC50	10.0 nM	PMID25330258	ChEMBL
IC50	10.0 nM	PMID25330258	BindingDB
Inhibition	99.1 %	PMID25330258	ChEMBL

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