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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2a
Synonym	CA2-47 alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2D adrenergic receptor Alpha-2AAR Alpha-2A adrenoreceptor Alpha-2A adrenoceptor adrenergic receptor Adrenergic alpha 2A receptor ADRA2R ADRA2 Adra-2a Adra-2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	450
Amino acid sequence	MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P22909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL327
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	2-Chloro-1-(3,4-dibromo-2-thienyl)-1-ethanone
Molecular formula	C6H3Br2ClOS
IUPAC name	2-chloro-1-(3,4-dibromothiophen-2-yl)ethanone
Molecular weight	318.407
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.6
Synonyms	2-chloro-1-(3,4-dibromothiophen-2-yl)ethanone CHEMBL357136 KS-00001YZZ AC1MC9G1 CTK6H4760 SCHEMBL6788266 BDBM7868 KB-86445 62673-71-6 chlorodibromothienylethanone MolPort-001-760-565 2-(Chloroacetyl)-3,4-dibromothiophene AJ-47041 DVHYHNZCCIEQQA-UHFFFAOYSA-N TR-063701 2-chloro-1-(3,4-dibromothiophen-2-yl)ethan-1-one KM0648 6Y-0810 Chloromethyl Thienyl Ketone deriv. 16 RP16453 2-Chloro-1-(3,4-dibromo- thiophen-2-yl)-ethanone AKOS005070889 KB-169254 ZINC3884176 [ Show all ]
Inchi Key	DVHYHNZCCIEQQA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H3Br2ClOS/c7-3-2-11-6(5(3)8)4(10)1-9/h2H,1H2
PubChem CID	2764204
ChEMBL	CHEMBL357136
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>10.0 %	PMID19747834	ChEMBL

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