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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS001173561
Molecular formula	C28H28N2
IUPAC name	N,N'-dibenzhydrylethane-1,2-diamine
Molecular weight	392.546
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	5.7
Synonyms	benzhydryl-[2-(benzhydrylamino)ethyl]amine GTPL1441 N,N'-bis[di(phenyl)methyl]ethane-1,2-diamine STL321288 AC1LZ7DF CHEBI:92409 NCGC00092383-02 AMN-082 cid_1894361 N,N''-dibenzhydrylethane-1,2-diamine SCHEMBL8095249 ZINC19371887 BRD-K23335153-300-01-7 HMS2873J07 N,N'-dibenzhydrylethane-1,2-diamine AKOS003669868 MolPort-000-917-606 NCGC00092383-03 BDBM58360 D02ETA N,N'-bis(diphenylmethyl)ethane-1,2-diamine SMR000538659 C28H28N2 MCULE-6472306137 N,N'-Dibenzhydrylethylenediamine AMN 082 CHEMBL1387826 N,N''-bis(diphenylmethyl)ethane-1,2-diamine NCGC00092383-04 [ Show all ]
Inchi Key	DTZDSNQYNPNCPK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H28N2/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26/h1-20,27-30H,21-22H2
PubChem CID	1894361
ChEMBL	CHEMBL1387826
IUPHAR	1441
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	7079.5 nM	PubChem BioAssay data set	ChEMBL

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