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GPCR

Name	Free fatty acid receptor 4
Species	Homo sapiens (Human)
Gene	FFAR4
Synonym	PGR4 Omega-3 fatty acid receptor 1 O3FAR1 GT01 GPR129 GPR120 G-protein-coupled receptor GT01 G-protein coupled receptor PGR4 FFA4 receptor G-protein coupled receptor 129 G-protein coupled receptor 120 G protein-coupled receptor 129 G protein-coupled receptor 120 G-protein coupled receptor GT01 [ Show all ]
Disease	N/A
Length	377
Amino acid sequence	MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProt	Q5NUL3
Protein Data Bank	N/A
GPCR-HGmod model	Q5NUL3
3D structure model	This predicted structure model is from GPCR-EXP Q5NUL3.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5339
IUPHAR	127
DrugBank	BE0003399

Ligand

Name	linolenic acid
Molecular formula	C18H30O2
IUPAC name	(9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid
Molecular weight	278.436
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	5.9
Synonyms	LINOLENIC ACID (18:3 n-3) 9,12,15-Octadecatrienoic acid, (Z,Z,Z)- Linolenic acid, ~70% (GC) a-Linolenic acid MolPort-003-937-817 all-cis-9,15-Octadecatrienoic acid NCGC00091058-09 BDBM50240347 SBB069548 CC-29967 Tox21_111071 cis,cis-9,12,15-Octadecatrienoic acid UNII-F85N2YHE4E component DTOSIQBPPRVQHS-PDBXOOCHSA-N D0C5SV (9Z,12Z,15Z)-9,12,15-Octadecatrienoic acid EINECS 207-334-8 (Z,Z,Z)-Octadeca-9,12,15-trienoic acid HMS3649H05 9,12,15-all-cis-Octadecatrienoic acid Linolenic acid, 99% 9-cis,12-cis,15-cis-Octadecatrienoic acid M621 AJ-45651 NCGC00091058-04 alpha-Linolenic acid NCGC00259276-01 BSPBio_001376 SMR000857336 UNII-0JXR8F0V1Q component DTOSIQBPPRVQHS-PDBXOOCHSA-N cis-9,12,15-octadecatrienoic acid DSSTox_CID_5506 (9Z,12Z,15Z)-Octadecatrienoic acid HMS1361E18 KB-209139 linolenate 9,12,15-Octadecatrienoic acid, (9Z,12Z,15Z)- Linolenic acid, crude A-8311 MLS001336030 all-cis-9,12,15-Octadecatrienoate NCGC00091058-07 AN-45099 NSC2042 C18:3n-3,6,9 ST072192 cis,cis,cis-9,12,15-octadecatrienoate UNII-71M78END5S component DTOSIQBPPRVQHS-PDBXOOCHSA-N cis-delta9,12,15-Octadecatrienoic acid DTOSIQBPPRVQHS-PDBXOOCHSA-N (Z,Z,Z)-9,12,15-Octadecatrienoate HMS2233C13 38660-45-6 (potassium salt) Linolenic acid (8CI) 9,15-Octadecatrienoic acid, (Z,Z,Z)- LMFA01030152 AC1NQXSA NCGC00091058-01 alpha-LA NCGC00091058-10 BML3-B05 SC-65260 CCRIS 656 Tox21_201727 cis-9, cis-12, cis-15-octadecatrienoic acid UNII-HBA528N3PW component DTOSIQBPPRVQHS-PDBXOOCHSA-N D0Z0FZ (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid FA005 .alpha.-Linolenic acid IDI1_033846 68424-45-3 9,12,15-Octadecatrienoate Linolenic acid, >=99% 94138-91-7 (lithium salt) MFCD00065720 AK106170 NCGC00091058-05 alpha-Linolenic acid, 1.0 mg/mL in ethanol, certified reference material NSC 2042 C06427 SR-01000838327 CHEMBL8739 UNII-0RBV727H71 cis-9,cis-12,cis-15-Octadecatrienoic acid DSSTox_GSID_25506 (9Z,12Z,15Z)octadeca-9,12,15-trienoic acid HMS1791E18 22333-90-0 (calcium salt) L000707 9,12,15-Octadecatrienoic acid, (9Z,12Z,15Z)- (9CI) Linolenic acid, Vetec(TM) reagent grade, 98% a-Linolenate MLS002454413 all-cis-9,12,15-Octadecatrienoic acid NCGC00091058-08 AX8136381 Octadecatrienoic acid, 9,12,15-(Z,Z,Z)- CAS-463-40-1 ST24034988 cis,cis,cis-9,12,15-Octadecatrienoic acid UNII-96GS7P39SN component DTOSIQBPPRVQHS-PDBXOOCHSA-N CMC_7371 (9,12,15)-linolenic acid DTXSID7025506 (Z,Z,Z)-9,12,15-Octadecatrienoic acid HMS3402E18 463-40-1 Linolenic acid 10 microg/mL in Methanol 9-cis,12-cis,15-cis-octadecatrienoate LNL AI3-23986 NCGC00091058-02 alpha-Linolenate NCGC00257192-01 BRD-K33396764-001-02-0 SCHEMBL15282 CHEBI:27432 Tox21_303322 cis-9,12,15-octadecatrienoate DB00132 (9Z,12Z,15Z)-Octadecatrienoate GTPL1049 0RBV727H71 Industrene 120 85392-75-2 (tin(2+) salt) ZINC3802189 9,12,15-Octadecatrienoic acid Linolenic acid, analytical standard 9Z,12Z,15Z-Octadecatrienoic acid MLS001336029 AKOS016008598 NCGC00091058-06 alpha-Lnn NSC-2042 C18:3 SR-01000838327-2 cid_5280934 UNII-5U9XZ261ER component DTOSIQBPPRVQHS-PDBXOOCHSA-N cis-Delta(9,12,15)-octadecatrienoic acid DSSTox_RID_77815 (all-Z)-9,12,15-Octadecatrienoic acid HMS1989E18 2DCD0473-E5CC-47BB-A0A4-95899AFF6C4B L0050 [ Show all ]
Inchi Key	DTOSIQBPPRVQHS-PDBXOOCHSA-N
Inchi ID	InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-
PubChem CID	5280934
ChEMBL	CHEMBL8739
IUPHAR	1049
BindingDB	50240347
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	100.0 %	PMID19007110	ChEMBL
EC50	2600.0 nM	PMID19007110	BindingDB,ChEMBL
EC50	3162.28 nM	PMID22519963	IUPHAR
EC50	3235.94 nM	PMID22519963	BindingDB,ChEMBL
Efficacy	99.0 %	PMID22519963	ChEMBL

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